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PROGRAM

 

Thursday, 31st October
Arrival/Registration
18:00-18:10 Opening Remarks

18:10-19:30

 

Session 1 Chair:Feng Rao
18:10-18:30 Xing Wang Deng (Peking University, Southern University of Science and Technology)
Light regulates nuclear detainment of intron-retained transcripts through COP1-spliceosome to modulate photomorphogenesis
18:30-18:50 Ning Zheng (University of Washington, Howard Hughes Medical Institute)
Converging Mechanisms of Cancer Mutations and A Molecular Glue Degrader
18:50-19:10 Hsueh-Chi Sherry Yen (Academia Sinica)
Rewiring of Cooperative Stabilization Networks in PCI complexes
19:10-19:30 Wolfgang Dubiel (Otto von Guericke University)
The COP9 signalosome: The regulator of CRLs
Welcome Reception

Friday, 1st November

08:30-10:40

 

Session 2 Chair:Qi Xie
08:30-09:10 Keynote: Daniel Finley (Harvard Medical School)
Global remodeling of the proteome in terminal differentiation
09:10-09:30 Brenda A. Schulman (Max Planck Institute of Biochemistry)
Structural insights into proteasome assemblies
09:30-09:50 Min Jae Lee (Seoul National University)
Stress responding mechanisms of the 26S proteasome and their pathological implications
09:50-10:10 Wei Li (Guangzhou Medical University)
Separately prestored proteasome components to prevent polyspermy
10:10-10:25 Kefeng Lu (Sichuan University)
AMP Synthesis Inhibition-Proteasome Promotes Proteostasis Mediated Longevity and Health Span across Species
10:20-10:40 Xing Guo (Zhejiang University)
Proteasome Regulation in Health and Disease
Tea/Coffee Break

11:10-12:10

 

Session 3 Chair:Qi Xie
11:10-11:30 Mong-Hong Lee (Sun Yat-sen University)
Deregulation of CSN6-SPOP-HMGCS1 axis promotes hepatocellular carcinoma progression
11:30-11:50 Michael Naumann (Otto von Guericke University)
Control of ADP-heptose-induced NF-kB activity by CSN-associated USP48 in the Helicobacter pylori infected gastric mucosa
11:50-12:10 Ceshi Chen (Kunming Medical University)
Hectd3 inhibits tumor growth by reversing immunosuppressive protumoral properties of TAM
Lunch

13:30-15:35

 

Session 4 Chair:Xing Wang Deng
13:30-13:50 Ning Wei (Southwest University)
Functions of the COP9 signalosome (CSN) as a regulator of SCF EBF-PIF3 in Arabidopsis thaliana and SCF Grr-A in Beauveria bassiana
13:50-14:10 Giovanna Serino (Sapienza University)
Regulation of CRL neddylation dynamics upon osmotic stress
14:10-14:30 Hongtao Liu (Shenzhen University)
The blue-light receptor CRY1 serves as a switch to balance photosynthesis and defense
14:30-14:50 Vicente Rubio (National Center for Biotechnology)
Hormone-mediated disassembly and inactivation of a plant E3 ubiquitin ligase complex
14:50-15:05 Ruixi Li (Southern University of Science and Technology)
The adaptor protein AP-3¦Â disassembles heat-induced stress granules via 19S RP-associated deubiquitylation in Arabidopsis
15:05-15:20 Saikat Bhattacharjee (Regional Center for Biotechnology)
Arabidopsis inositol polyphosphate kinases regulate COP9 signalosome activities in phosphate homeostasis.
15:20-15:35 Li Yang (China Agricultural University)
COP1-Mediated Ubiquitination of the Salicylic Acid Receptor: A Key Mechanism in Regulating Plant Immunity
Tea/Coffee Break

15:55-18:10

 

Session 5 Chair: Ning Zheng
15:55-16:15 Gerhard H. Braus (Georg-August University)
The fungal COP9 signalosome and the velvet domain transcriptional regulators coordinate development and secondary metabolism in Aspergillus nidulans
16:15-16:35 Yi Sun (Zhejiang University)
Targeting protein neddylaFtion and Cullin-RING ligase for anti-cancer therapy
16:35-16:55 Lan Huang (University of California)
Understanding the Structure and Function of the COP9 Signalosome Through Protein-Protein Interactions
16:55-17:15 Jurgen Bernhagen (LMU University Hospital)
Protective Role of the COP9 Signalosome in Cardiovascular and Neurovascular Disease
17:15-17:30 Dawadschargal Dubiel (University Magdeburg)
COP9 signalosome (CSN) is a substrate of autophagy
17:30-17:45 Xu Tan (Chinese Institutes for Medical Research)
Genetics, Mechanism and Therapy for A Mendelian Syndrome and How It Might Help With Hair Loss
17:45-18:00 Ziqing Yu (National Institute of Biological Sciences)
A nature-inspired HIF stabilizer derived from a highland-adaptation insertion of plateau pika Epas1 protein
18:00-18:10 Tao Chen (Absea)
Platforms and Resources for Proteomics and Beyond
18:20-19:20 Conference Dinner
19:20-21:20 Poster Session

Saturday, 2nd November

08:30-10:30

 

Session 6 Chair:Dieter A. Wolf
08:30-09:10 Keynote: Mo-Fang Liu (Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences)
Regulation of Male Reproductive Health from an RNA Perspective
09:10-09:30 Yaser Hashem (University de Bordeaux)
Structural insights into the mammalian late-stage translation initiation navigated by trans-RNAs
09:30-09:50 Ayala Shiber (Technion-Israel Institute of Technology)
Identification and Characterization of Novel Quality Control Factors on the Ribosome
09:50-10:10 Baochun Han (Westlake Universitys)
5`-UTR-mediated tethering of eIF3 to 80S ribosomes promotes co-translational protein folding of ER membrane proteins
10:10-10:30 Yihong Ye (National Institute of Diabetes, Digestive & Kidney Diseases)
NEMF-mediated CAT-tailing in ribosome-associated quality control at the endoplasmic reticulum
Tea/Coffee Break & Poster vote

10:45-12:20

 

Session 7 Chair: Brenda A. Schulman
10:50-11:10 Lei Liu (Tsinghua University)
Applications of chemical protein synthesis in studying ubiquitin biochemistry
11:10-11:30 Jianping Jin (Zhejiang University)
Regulating constitutive activation of NF-¦ÊB signaling by ubiquitin ligase BRAP
11:30-11:50 Michael H. Glickman (Technion-Israel Institute of Technology)
A fourth proteasome-associated DUB?
11:50-12:10 Xingzhi Xu (Shenzhen University)
Regulation of the ATR-CHK1 checkpoint signaling
Lunch

13:30-14:55

 

Session 8 Chair:Ning Wei
13:30-13:50 Dimitris Xirodimas (University of Montpellier)
A nuclear Protein Quality Control system for the elimination of nucleolus-related inclusions
13:50-14:10 Han-ming Shen (University of Macau)
Characterization of the ubiquitination code mediated by Parkin in the course of mitophagy
14:10-14:25 Yingying Lin (Hangzhou Normal University)
CCT7 functions as monosome for clearance of ALS- related aggregates
14:25-14:40 Yanfen Liu (ShanghaiTech University)
Protein Quality Control Regulates Stress Granule Homeostasis
14:40-14:55 Zhouhua Li (Capital Normal University)
Multi-dimensional analyses reveal antagonism between JAK/STAT downstream targets UBR5 and Drumstick in stem cell regulation and cell fate conversion

Sunday, 3rd November

 

 

08:30-10:20

 

Session 9 Chair: Hai Rao
08:30-09:10 Keynote: Tom A. Rapoport (Harvard Medical School)
MECHANISM OF PROTEIN IMPORT INTO PEROXISOMES
09:10-09:30 Xinhua Feng (Zhejiang University)
A Non-E3 Function of Ubiquitin Ligase HERC3
09:30-09:50 Feng Rao (Southern University of Science and Technology)
FAST is a fatty acid-sensing/transducing E3 complex that safeguards lipid droplet homeostasis to prevent lipotoxic disorders
09:50-10:10 Min Zhuang (ShanghaiTech University)
The role of ubiquitin ligase MARCH5 in peroxisome homeostasis
10:10-10:25 Kai Liu (Wuhan University)
Molecular basis for the stepwise and faithful assembly and maturation of the 20S proteasome
Tea/Coffee Break

10:45-12:05

 

Session 10 Chair:Dimitris Xirodimas
10:45-11:05 Xiao-Bo Qiu (Beijing Normal University)
Direct proteasomal degradation of target proteins by non-ubiquitin PROTAC, NuTAC
11:05-11:25 Hai Rao (Southern University of Science and Technology)
Mini-PROTACs
11:25 11:40 Chao Xu (University of Science and Technology of China)
C-degron-mediated proteostasis and its implication in PROTAC design
11:40-11:50 Khristin Riching (Promega)
Enabling discovery and optimization of therapeutic targeted protein degraders
11:50-12:00 summary
12:00 Departure